Phosgene → (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride
Reaction equation
S(Cl)(Cl)=O.[C:5]([Cl:8])(Cl)=[O:6].[F:9][CH:10]([F:25])[O:11][C:12]1[CH:17]=[CH:16][C:15]([C@H:18]([CH:22]([CH3:24])[CH3:23])C(O)=O)=[CH:14][CH:13]=1>>[F:9][CH:10]([F:25])[O:11][C:12]1[CH:17]=[CH:16][C:15]([C@H:18]([CH:22]([CH3:23])[CH3:24])[C:5]([Cl:8])=[O:6])=[CH:14][CH:13]=1Participants
4
Procedure
Add 1-3 moles of thionyl chloride or phosgene into (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyric acid, and allow the mixture to react at 10° C. to reflux temperature of the solvent for 0.1-100 hours, preferably for 1-5 hours. After the reaction is completed, distill off the unreacted thionyl chloride or phosgene to give the (S)-2-(4-difluoromethoxyphenyl)-3-methylbutyryl chloride.