(2-{5-[5-(5-chloro-2-oxo-2H-[1,2']bipyridinyl-5'-ylmethyl)-imidazol-1-ylmethyl]-2-cyano-phenoxy}-ethyl)-carbamic acid tert-butyl ester → 2-(2-Amino-ethoxy)-4-[5-(5-chloro-2-oxo-2H-[1,2']bipyridinyl-5'-ylmethyl)-imidazol-1-ylmethyl]-benzonitrile
Reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[C:15]([CH2:17][N:18]2[C:22]([CH2:23][C:24]3[CH:25]=[CH:26][C:27]([N:30]4[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]4=[O:37])=[N:28][CH:29]=3)=[CH:21][N:20]=[CH:19]2)[CH:14]=[CH:13][C:12]=1[C:38]#[N:39])(C)(C)C>CO>[NH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[C:15]([CH2:17][N:18]2[C:22]([CH2:23][C:24]3[CH:25]=[CH:26][C:27]([N:30]4[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]4=[O:37])=[N:28][CH:29]=3)=[CH:21][N:20]=[CH:19]2)[CH:14]=[CH:13][C:12]=1[C:38]#[N:39]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
(2-{5-[5-(5-chloro-2-oxo-2H-[1,2']bipyridinyl-5'-ylmethyl)-imidazol-1-ylmethyl]-2-cyano-phenoxy}-ethyl)-carbamic acid tert-butyl ester from step 4 (260 mg, 0.46 mmol) was dissolved in MeOH (15 ml) and cooled to 0° C. HCl(g) was then bubbled into the solution until saturated. The reaction mixture was allowed to warm up to room temperature. The solvent was removed in vacuo to yield the final product.