HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3',4'-dihydroxyacetophenone → 2-(3,4-Dimethoxyphenyl)-4-(3,4-dihydroxyphenyl)thiazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3',4'-dihydroxyacetophenone | HCID 66834 | — |
| Reactant | 3,4-Dimethoxythiobenzamide | HCID 2758490 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(3,4-Dimethoxyphenyl)-4-(3,4-dihydroxyphenyl)thiazole hydrochloride | HCID 18707355 | 22.2% |
Reaction Steps
In 20 ml of ethanol were suspended 367 mg of 3',4'-dihydroxy-2-chloroacetophenone and 430 mg of 3,4-dimethoxythiobenzamide. The suspension was refluxed for 3 hours with heating. After cooling, the resulting crystals were collected by filtration, ethanol-washed and dried. The dried material was recrystallized from ethanol to obtain 160 mg of 2-(3,4-dimethoxyphenyl)-4-(3,4-dihydroxyphenyl)thiazole hydrochloride as yellow acicular crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06080764 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-6114db3fffff415281ee0e1682dfb883 |
| Source note | uspto-grants-2000_06 |