Ethyl cis(+/-)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-3-carboxylate → Ethyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)pyridine-3-carboxylate
Reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH:21]=[N:22][CH:23]=2)[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH:21]=[N:22][CH:23]=2)[CH2:14][C@H:13]1[O:29][CH3:30]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The same operation as in Example (160c) was performed using methyl cis(±)-4-(4-{[benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-2-carboxylate obtained in Example (162a) (436 mg) and a 10% palladium-carbon catalyst (500 mg), to obtain 137.5 mg of the title compound as a colorless oily substance. The resulting compound was used for the next reaction without purification.
Sources & evidence
- ORD record
- ord-b76dc1d8d4b2433d90bba010a41d387d
- Source dataset
- uspto-grants-2015_01
- Patent number
- US08927588B2
Reaction notes
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