1,2-Dibromoethane → 1-(5-Bromopyridin-2-yl)cyclopropane-1-carbonitrile

Reaction equation

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]#[N:10])=[N:6][CH:7]=1.Br[CH2:12][CH2:13]Br>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:9]#[N:10])[CH2:13][CH2:12]2)=[N:6][CH:7]=1

Participants

Reactant 2

HCID 78391,2-Dibromoethane

HCID 299278812-(5-Bromopyridin-2-yl)acetonitrile

Product 1

HCID 534029901-(5-Bromopyridin-2-yl)cyclopropane-1-carbonitrileYield 88%

Procedure

Alternatively, the title compound was prepared from (5-bromo-pyridin-2-yl)-acetonitrile and 1,2-dibromoethane following a procedure analogous to that described in Step 3 for Intermediate 4. Yield: 88% of theory.

Sources & evidence

ORD record: ord-29a817a26e704759aa05a38de4fd3cfe
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08933072B2

Reaction notes

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