1-Ethynyl-3-fluorobenzene → HCID 53245752, compound

Reaction equation

Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)[N:10]=2)[CH:7]=1.[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=1)#[CH:18]>>[F:25][C:21]1[CH:20]=[C:19]([C:17]#[C:18][C:2]2[CH:3]=[N:4][C:5]3[N:6]([N:8]=[C:9]([N:11]4[CH2:16][CH2:15][O:14][CH2:13][CH2:12]4)[N:10]=3)[CH:7]=2)[CH:24]=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 5202181-Ethynyl-3-fluorobenzene

HCID 58316703HCID 58316703, compound

Product 1

HCID 53245752HCID 53245752, compound

Procedure

The title compound, a light brown solid, MS: m/e=324.3 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyrimidine (example 47, step 1) and ethynyl-3-fluorobenzene.

Sources & evidence

ORD record: ord-6a12e0ee2c3e4238a8a100750cccc510
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08933094B2

Reaction notes

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