HCID 68233453, compound → (R,E)-4-Amino-5-phenylpent-2-enenitrile
Reaction equation
C(OC(=O)[NH:7][C@@H:8](/[CH:16]=[CH:17]/[C:18]#[N:19])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C>Cl.CO>[NH2:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)/[CH:16]=[CH:17]/[C:18]#[N:19]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Compound 31e (4.0 g, 14.7 mmol) was treated with 2M HCl/MeOH (300 mL). After the reaction was over, the solvents were removed under reduced pressure to give a white solid. The product was directly used in the next reaction step without further purification.
Workup
- customwere removed under reduced pressure
- customto give a white solid
- customThe product was directly used in the next reaction step without further purification
Sources & evidence
- ORD record
- ord-19eb24d404ee4e0ababa86f73d24d572
- Source dataset
- uspto-grants-2015_01
- Patent number
- US08940722B2
Reaction notes
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