HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 4-Chloropyridine-2-carboximidamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 4-Chloro-2-pyridinecarbonitrile | HCID 693342 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Chloropyridine-2-carboximidamide hydrochloride | HCID 21882000 | — |
Reaction Steps
6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07612010B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-240063da68164b27b7977e65dd3e8129 |
| Source note | uspto-grants-2009_11 |