Sodium Hydroxide → 4,5,6,7-Tetrahydro-1,3-benzothiazole-5-carboxylic acid
Reaction equation
[OH-].[Na+].[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([O:14]CC)=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1>CO>[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([OH:14])=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
6 ml of 2N NaOH are added to a solution of 0.42 g of ethyl 4,5,6,7-tetrahydrobenzothiazole-5-carboxylate [952203-30-8] and 24 ml of MeOH at room temperature. After 6 hours, the reaction mixture is evaporated. The residue is acidified with 4N HCl, diluted with water and extracted with ethyl acetate (2×)—the combined organic phases are dried with sodium sulphate and evaporated. The crude title compound is obtained from the residue.
Workup
- customthe reaction mixture is evaporated
- additiondiluted with water
- extractionextracted with ethyl acetate (2×)—the combined organic phases
- dry with materialare dried with sodium sulphate
- customevaporated
Sources & evidence
- ORD record
- ord-2d395f3bf35e485a8aeafc3f85cc22c1
- Source dataset
- uspto-grants-2009_11
- Patent number
- US07612088B2
Reaction notes
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