Acetic Acid → Temozolomide

HRID 1433126Notes

Reaction equation

HRID 1433126 reaction equation
[CH3:1][N:2]1[N:11]=[N:10][C:9]2[N:5]([CH:6]=[N:7][C:8]=2[C:12]([NH2:14])=[O:13])[C:3]1=[O:4].Cl.C(O)(=O)C.C(#N)C>O>[CH3:1][N:2]1[N:11]=[N:10][C:9]2[N:5]([CH:6]=[N:7][C:8]=2[C:12]([NH2:14])=[O:13])[C:3]1=[O:4]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6342AcetonitrileHCID 11658676HCID 11658676, compound

Product 1

HCID 5394Temozolomide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the present invention, the dissolution of Temozolomide hydrochloride in the mixture of acetic acid, acetonitrile, and water is complete (at pH range of 3-4), results in the precipitation of Temozolomide upon cooling.

Sources & evidence

ORD record
ord-73fd4603a2d447539955f29b9ce3c3ea
Source dataset
uspto-grants-2009_11
Patent number
US07612202B2

Reaction notes

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