6-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate → 7-Methoxy-3-(4-methoxy-2-nitrophenyl)-1,2-dihydronaphthalene

HRID 1433862

Reaction equation

HRID 1433862 reaction equation
FC(F)(F)S(O[C:7]1[CH2:16][CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=2)[CH:8]=1)(=O)=O.C([Sn](CCCC)(CCCC)[C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=1[N+:34]([O-:36])=[O:35])CCC>>[CH3:18][O:17][C:12]1[CH:13]=[C:14]2[C:9]([CH:8]=[C:7]([C:26]3[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=3[N+:34]([O-:36])=[O:35])[CH2:16][CH2:15]2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 153302566-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonateHCID 23087474Tributyl(4-methoxy-2-nitrophenyl)tin

Product 1

HCID 230871417-Methoxy-3-(4-methoxy-2-nitrophenyl)-1,2-dihydronaphthaleneYield 73.2%

Procedure

Synthesized from 6-methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate (2.3 g) and tributyl(4-methoxy-2-nitrophenyl)tin (3.9 g) according to an analogous synthetic method to Preparation Example 77, the title compound (1.7 g) was obtained.

Workup

  1. customaccording to an analogous synthetic method to Preparation Example 77

Sources & evidence

ORD record
ord-93695c5539284e51b554a25583905b0f
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Linked notes

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