2-Methoxy-8,9-dihydro-5H-benzo[7]annulen-6(7H)-one → 3-Methoxy-8-(4-methoxy-2-nitrophenyl)-6,7-dihydro-5H-benzocycloheptene

HRID 1433891Notes

Reaction equation

HRID 1433891 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][C:11](=O)[CH2:10][CH2:9][CH2:8][C:7]=2[CH:14]=1.FC(F)(F)S(OC1CCCC2C=C(OC)C=CC=2C=1)(=O)=O.C([Sn](CCCC)(CCCC)[C:41]1[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[CH:43][C:42]=1[N+:49]([O-:51])=[O:50])CCC>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:12]=[C:11]([C:41]3[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[CH:43][C:42]=3[N+:49]([O-:51])=[O:50])[CH2:10][CH2:9][CH2:8][C:7]=2[CH:14]=1

Participants

4

Reactant 3

HCID 123691772-Methoxy-8,9-dihydro-5H-benzo[7]annulen-6(7H)-oneHCID 23087474Tributyl(4-methoxy-2-nitrophenyl)tinHCID 86605238HCID 86605238, compound

Product 1

HCID 666269683-Methoxy-8-(4-methoxy-2-nitrophenyl)-6,7-dihydro-5H-benzocycloheptene

Procedure

Synthesized from 2-methoxy-5,7,8,9-tetrahydrobenzocyclohepten-6-one according to an analogous synthetic method to Preparation Example 82, 2-methoxy-8,9-dihydro-7H-benzocyclohepten-6-yl trifluoromethanesulfonate (3.0 g) and tributyl(4-methoxy-2-nitrophenyl)tin (10.8 g) were used according to an analogous synthetic method to Preparation Example 77 to provide the title compound (2.8 g).

Workup

  1. customwere used according to an analogous synthetic method to Preparation Example 77

Sources & evidence

ORD record
ord-da2c626018c74dd2bd3ba753b6f2cbb0
Source dataset
uspto-grants-2009_11
Patent number
US07612114B2

Reaction notes

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