4-Amino-2,2,6,6-tetramethylpiperidine → 4-{5-[5-Methyl-2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butyric acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][C:7]1[S:8][C:9]([C:12]2[C:17]([CH3:18])=[CH:16][N:15]=[C:14](Cl)[N:13]=2)=[CH:10][CH:11]=1.[CH3:21][C:22]1([CH3:31])[CH2:27][CH:26]([NH2:28])[CH2:25][C:24]([CH3:30])([CH3:29])[NH:23]1>>[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][C:7]1[S:8][C:9]([C:12]2[C:17]([CH3:18])=[CH:16][N:15]=[C:14]([NH:28][CH:26]3[CH2:27][C:22]([CH3:31])([CH3:21])[NH:23][C:24]([CH3:30])([CH3:29])[CH2:25]3)[N:13]=2)=[CH:10][CH:11]=1Participants
3
Procedure
4-{5-[5-Methyl-2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butyric acid methyl ester was prepared analogous to Step C of Method A, starting from 4-[5-(2-chloro-5-methyl-pyrimidin-4-yl)-thiophen-2-yl]-butyric acid methyl ester and added 2,2,6,6-tetramethyl-piperidin-4-ylamine. Yield: 60%.