Water → Ethyl 2-mercapto-2-methylpropionate
Reaction equation
Br[C:2]([CH3:9])([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].O.[SH-:11].[Na+].O>C(O)C>[CH2:6]([O:5][C:3](=[O:4])[C:2]([SH:11])([CH3:9])[CH3:8])[CH3:7]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Ethyl 2-bromoisobutyrate (48.8 g, 0.250 mole), sodium hydrosulfide hydrate (84 g, 1.5 mole), water (100 mL), ethyl alcohol (200 mL). Let reaction mix stir at room temperature. Next day, no starting material observed. Crude yield: 74.3%; distillation yield: 36.0%.
Workup
- customreaction
- additionmix
- distillationdistillation yield: 36.0%
Sources & evidence
- ORD record
- ord-e75733b00fb949a88f3a90873c089504
- Source dataset
- uspto-grants-2009_11
- Patent number
- US07615661B2
Reaction notes
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