tert-Butyl pentanoate → HCID 178444126, compound

HRID 1435552

Reaction equation

HRID 1435552 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[CH2:14][CH2:13][C@H:12]([CH:15]3[CH2:18][CH2:17][O:16]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[C:19]([O:23][C:24](=[O:29])[CH2:25][CH2:26][CH2:27][CH3:28])([CH3:22])([CH3:21])[CH3:20]>>[CH2:26]([CH:25]([CH2:17][CH2:18][CH:15]([OH:16])[C@H:12]1[CH2:11][CH2:10][C@H:9]([C:6]2[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=2)[CH2:14][CH2:13]1)[C:24]([O:23][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:29])[CH2:27][CH3:28]

Participants

3

Reactant 2

HCID 520048tert-Butyl pentanoateHCID 178436316HCID 178436316, compound

Product 1

HCID 178444126HCID 178444126, compoundYield 93.2%

Procedure

Reaction operations were carried out according to the first step of Example 1 by using 2-(trans-4-(4-ethylphenyl)cyclohexyl)oxetane (42) (7.5 g, 30.9 mmol) and tert-butylpentanoate (43) (15.6 g, 98.9 mmol) as starting materials to obtain tert-butyl 2-propyl-5-hydroxy-5-(trans-4-(4-ethylphenyl)cyclohexyl)pentanoate (44) (11.6 g, 28.8 mmol). The yield based on the compound (42) was 93%.

Workup

  1. customReaction operations

Sources & evidence

ORD record
ord-343a81b8b62f4e2badce0857eac8d6c0
Source dataset
uspto-grants-2009_11
Patent number
US07618688B2

Linked notes

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