4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl (2-{[(3-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

HRID 1435652

Reaction equation

HRID 1435652 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:13]([C:15]1[CH:16]=[C:17]([S:21](Cl)(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=1)#[N:14]>>[C:13]([C:15]1[CH:16]=[C:17]([S:21]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=1)#[N:14]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 28013603-Cyanobenzene-1-sulfonyl chloride

Product 1

HCID 10132641Ethyl (2-{[(3-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 3-cyanobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (39.4 mg) with purity >90%. MS (pos) m/z 352.3.

Sources & evidence

ORD record
ord-e54701ffb7434d2d9c93745ef21212de
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Linked notes

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