7-(Hydroxymethyl)-1H-pyrido[2,3-b][1,4]thiazin-2(3H)-one → 2-Oxo-2,3-dihydro-1h-pyrido[2,3-b][1,4]thiazine-7-carbaldehyde

HRID 1435863

Reaction equation

HRID 1435863 reaction equation
[OH:1][CH2:2][C:3]1[CH:13]=[N:12][C:6]2[S:7][CH2:8][C:9](=[O:11])[NH:10][C:5]=2[CH:4]=1>[O-2].[O-2].[Mn+4]>[O:11]=[C:9]1[CH2:8][S:7][C:6]2[N:12]=[CH:13][C:3]([CH:2]=[O:1])=[CH:4][C:5]=2[NH:10]1

Participants

3

Reactant 1

HCID 218737287-(Hydroxymethyl)-1H-pyrido[2,3-b][1,4]thiazin-2(3H)-one

Product 1

HCID 218737332-Oxo-2,3-dihydro-1h-pyrido[2,3-b][1,4]thiazine-7-carbaldehydeYield 58%

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

7-Hydroxymethyl-1H-pyrido[2,3-b][1,4]thiazin-2-one (1.22 g) was oxidized with manganese dioxide by the method of Preparation (14c) to afford a solid (0.7 g).

Sources & evidence

ORD record
ord-6ee8c8a29da446ae8d6051bba5e25b35
Source dataset
uspto-grants-2009_11
Patent number
US07618959B2

Linked notes

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