Isothiocyanatopotassium → 1-(4-Chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone
Reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([F:12])[CH:6]=1)=[O:4].[N-:13]=[C:14]=[S:15].[K+]>C(O)C>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][S:15][C:14]#[N:13])=[CH:6][C:7]=1[F:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In the same manner as described in step 4 of Example 78, using 2-bromo-1-(4-chloro-3-fluoro-phenyl)-ethanone (2.7 g, 10.7 mmol), prepared in the previous step, and potassium isothiocyanate (1.25 g, 12.8 mmol) in ethanol (150 mL) the crude product was collected by suction filtration to give 1-(4-chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone (2.47 g, 100%), which was used in the next step without further purification. MS (ES) m/z 230[M+H+].
Workup
- filtrationwas collected by suction filtration
Sources & evidence
- ORD record
- ord-7e06f8fe6fc743dfb43f3131c67df4b5
- Source dataset
- uspto-grants-2009_11
- Patent number
- US07618990B2
Reaction notes
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