Methyl 3-(1-methyl-2-oxocyclohexyl)propanoate → 6-Propyl-1,4-dioxospiro[4.5]decane-6-propionic acid methyl ester

HRID 1438919Notes

Reaction equation

HRID 1438919 reaction equation
COC(=O)CCC1(C)CCCCC1=O.COC(=O)CCC1(CC)CCCCC1=O.[CH3:30][O:31][C:32](=[O:45])[CH2:33][CH2:34][C:35]1([CH2:42][CH2:43][CH3:44])[CH2:40][CH2:39][CH2:38][CH2:37][C:36]1=O.COC(=O)CCC1(CC)CCCCC21[C:56](=[O:57])[CH2:55][CH2:54][C:53]2=[O:58]>>[CH3:30][O:31][C:32](=[O:45])[CH2:33][CH2:34][C:35]1([CH2:42][CH2:43][CH3:44])[CH2:40][CH2:39][CH2:38][CH2:37][C:36]21[C:56](=[O:57])[CH2:55][CH2:54][C:53]2=[O:58]

Participants

5

Reactant 4

HCID 574325Methyl 3-(1-methyl-2-oxocyclohexyl)propanoateHCID 122918881-Ethyl-2-oxocyclohexanepropionic acid methyl esterHCID 227572861-Propyl-2-oxocyclohexanepropionic methyl esterHCID 536692706-Ethyl-1,4-dioxospiro[4.5]decane-6-propionic acid methyl ester

Product 1

HCID 537697746-Propyl-1,4-dioxospiro[4.5]decane-6-propionic acid methyl ester

Procedure

In the same manner but replacing 1-methyl-2-oxocyclohexane-propionic acid methyl ester with an equivalent amount of 1-ethyl-2-oxocyclohexanepropionic acid methyl ester or 1-propyl-2-oxocyclohexanepropionic acid methyl ester, described in Example 6, 6-ethyl-1,4-dioxospiro[4.5]decane-6-propionic acid methyl ester, νmaxCHCl3 1730 cm-1 and 6-propyl-1,4-dioxospiro[4.5]decane-6-propionic acid methyl ester, νmaxCHCl3 1735 cm-1, are obtained, respectively.

Sources & evidence

ORD record
ord-09db9567a673434abc5decb49c43b491
Source dataset
uspto-grants-1977_11
Patent number
US04057559

Reaction notes

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