Thionyl Chloride → 3-Difluoromethoxy-2,4,5-trifluoro-6-nitrobenzoyl chloride
Reaction equation
S(Cl)([Cl:3])=O.[F:5][CH:6]([F:23])[O:7][C:8]1[C:9]([F:22])=[C:10]([C:14]([N+:19]([O-:21])=[O:20])=[C:15]([F:18])[C:16]=1[F:17])[C:11](O)=[O:12]>C1C=CC=CC=1>[F:5][CH:6]([F:23])[O:7][C:8]1[C:9]([F:22])=[C:10]([C:14]([N+:19]([O-:21])=[O:20])=[C:15]([F:18])[C:16]=1[F:17])[C:11]([Cl:3])=[O:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
40 ml of thionyl chloride were added to a solution of 15.97 g (0.056 moles) of 3-difluoromethoxy-2,4,5-trifluoro-6-nitrobenzoic acid [(XII), R1 =--OCHF2, R3' =NO2, X=X'=F] in 50 ml of benzene, and the mixture was heated under reflux for 2 hours. At the end of this time, the benzene and the excess thionyl chloride were removed by distillation under reduced pressure to give 16.50 g of 3-difluoromethoxy-2,4,5-trifluoro-6-nitrobenzoyl chloride [(XIII), R1 =--OCHF2, R3' =NO2, X=X'=F].