Methanol → 1-Methyl-3-n-propyl-2-iminoimidazolidin-4-one
Reaction equation
I.[CH3:2][N:3]1[CH2:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4]1=[NH:12].CO.[OH-].[K+]>>[CH3:2][N:3]1[CH2:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4]1=[NH:12]Participants
4
Procedure
2.83 g (10 mmol) of the 1-methyl-3-n-propyl-2-iminoimidazolidin-4-one hydroiodide was added to 25 ml of methanol containing 0.66 g (10 mmol) of 85% potassium hydroxide, and the mixture was stirred at room temperature for one hour. Methanol was distilled off under reduced pressure, and chloroform was added to the residue. Precipitated crystals were removed by filtration. Chloroform was distilled off under reduced pressure to obtain 1.16 g of 1-methyl-3-n-propyl-2 -iminoimidazolidin-4-one as an oily substance.
Workup
- distillationMethanol was distilled off under reduced pressure, and chloroform
- additionwas added to the residue
- customPrecipitated crystals
- customwere removed by filtration
- distillationChloroform was distilled off under reduced pressure
Sources & evidence
- ORD record
- ord-c08634c764ad4bdbb610fbcbf4502dd7
- Source dataset
- uspto-grants-1996_03
- Patent number
- US05500406
Reaction notes
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