(S)-2-chloro-cyclohex-2-enylamine → 3-Phenylpropanamide

Reaction equation

Cl[C:2]1[C@@H:3](N)[CH2:4][CH2:5][CH2:6][CH:7]=1.C1(=O)[N:13](N[C@H](C(O)=O)CC2C=CC=CC=2)[C:12](=[O:26])[C:11]2=CC=CC=[C:10]12>>[C:2]1([CH2:10][CH2:11][C:12]([NH2:13])=[O:26])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 10855491(S)-2-chloro-cyclohex-2-enylamine

HCID 22859636phthalimido-L-phenyalanine

Product 1

HCID 76253-Phenylpropanamide

Procedure

reacting (S)-2-chloro-cyclohex-2-enylamine with phthalimido-L-phenyalanine derivative to give (S)-N-(2-chloro-cyclohex-2-enyl)-2- 2(S)-1,3-dihydro-1,3-dioxo-isoindol-2-yl)-3-phenyl-propionamide;

Sources & evidence

ORD record: ord-8953d12736c74b5cb0379c538785edb7
Source dataset: uspto-grants-1996_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05502253

Reaction notes

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