Imidazole → 4-(1H-Imidazol-1-yl)-3-(trifluoromethyl)-benzonitrile

HRID 1441740

Reaction equation

Cl[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[N:14]1([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=2[C:10]([F:13])([F:12])[F:11])[CH:18]=[CH:17][N:16]=[CH:15]1

Participants

Reactant 2

HCID 795Imidazole

HCID 27364744-Chloro-3-(trifluoromethyl)benzonitrile

Product 1

HCID 666336134-(1H-Imidazol-1-yl)-3-(trifluoromethyl)-benzonitrile

Procedure

The title compound is prepared using an analogous method as described in Example 1.1, utilising 4-chloro-3-(trifluoromethyl)-benzonitrile (Lancaster Synthesis, GmbH) and imidazole (Fluka, Buchs, Switzerland), with a reaction temperature of 110° C.

Sources & evidence

ORD record: ord-8a144d5b61524a3d8d490a715cf2dd9e
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07655669B2

Linked notes

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