2-Methoxyquinolin-5-amine → 1,1,1-Trifluoro-4-phenyl-2-[(2-methoxyquinolin-5-yl)iminomethyl]-4-methylpentan-2-ol

HRID 1443174Notes

Reaction equation

HRID 1443174 reaction equation
[OH:1][C:2]([C:15]([F:18])([F:17])[F:16])([CH2:5][C:6]([CH3:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[CH:3]=O.[NH2:19][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[CH:22]=[CH:23][C:24]([O:30][CH3:31])=[N:25]2>>[F:18][C:15]([F:16])([F:17])[C:2]([CH:3]=[N:19][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[CH:22]=[CH:23][C:24]([O:30][CH3:31])=[N:25]2)([OH:1])[CH2:5][C:6]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([CH3:7])[CH3:14]

Participants

3

Reactant 2

HCID 122830362-Methoxyquinolin-5-amineHCID 179890922-Hydroxy-4-methyl-4-phenyl-2-trifluoromethylpentanal

Product 1

HCID 179892631,1,1-Trifluoro-4-phenyl-2-[(2-methoxyquinolin-5-yl)iminomethyl]-4-methylpentan-2-ol

Procedure

Analogously to Example 13, 200 mg of 2-hydroxy-4-methyl-4-phenyl-2-(trifluoromethyl)pentanal and 122 mg of 5-amino-2-methoxyquinoline are converted into 190 mg of product.

Sources & evidence

ORD record
ord-3493ae2510ab44938076d68041f2eaae
Source dataset
uspto-grants-2010_02
Patent number
US07659297B2

Reaction notes

Loading…