Ethyl 2-(4-bromophenyl)-2-methylpropanoate → alpha,alpha-Dimethyl-3-thiopheneacetic acid

Reaction equation

[CH3:1][C:2]([C:9]1[CH:13]=[CH:12][S:11][CH:10]=1)([CH3:8])[C:3]([O:5]CC)=[O:4].BrC1C=CC(C(C)(C)C(OCC)=O)=CC=1>>[CH3:8][C:2]([C:9]1[CH:13]=[CH:12][S:11][CH:10]=1)([CH3:1])[C:3]([OH:5])=[O:4]

Participants

Reactant 2

HCID 11277257Ethyl 2-(4-bromophenyl)-2-methylpropanoate

HCID 21099805Ethyl 2-methyl-2-(thiophen-3-yl)propanoate

Product 1

HCID 19092029alpha,alpha-Dimethyl-3-thiopheneacetic acid

Procedure

The title compound was prepared according to the method of Example 22B, substituting the product of Example 24A for the product of Example 22A.

Sources & evidence

ORD record: ord-3e9f17eaf9b547c7a4304ca40862efae
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE041135E1

Reaction notes

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