Ethyl 2-(4-bromophenyl)-2-methylpropanoate → 2-(1-Benzothiophen-3-yl)-2-methylpropanoic acid

Reaction equation

[S:1]1[CH:5]=[C:4]([C:6]([CH3:11])([CH3:10])[C:7]([O-:9])=[O:8])[C:3]2[CH:12]=[CH:13][CH:14]=[CH:15][C:2]1=2.BrC1C=CC(C(C)(C)C(OCC)=O)=CC=1>>[S:1]1[CH:5]=[C:4]([C:6]([CH3:11])([CH3:10])[C:7]([OH:9])=[O:8])[C:3]2[CH:12]=[CH:13][CH:14]=[CH:15][C:2]1=2

Participants

Reactant 2

HCID 11277257Ethyl 2-(4-bromophenyl)-2-methylpropanoate

HCID 867610552-(Benzo[b]thiophen-3-yl)-2-methylpropanoate

Product 1

HCID 210997132-(1-Benzothiophen-3-yl)-2-methylpropanoic acid

Procedure

The title compound was prepared according to the method of Example 22B substituting the product of Example 49B for the product of Example 22A.

Sources & evidence

ORD record: ord-819c4ffe65114bdd94b99b4ff13b4525
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE041135E1

Reaction notes

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