Hydrazine → 4-phenyl-1H-pyrazolo[5,4-c]pyridazin-3-amine
Reaction equation
Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]=1[C:8]#[N:9].[NH2:16][NH2:17]>C(O)C>[C:10]1([C:6]2[CH:5]=[N:17][N:16]=[C:2]3[NH:3][N:4]=[C:8]([NH2:9])[C:7]=23)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3-Chloro-5-phenyl-pyridazine-4-carbonitrile obtained from Step B was suspended in 1 mL ethanol with 23 μL hydrazine and the mixture was refluxed for several hours. The solvent was then evaporated and the title product was purified by silica gel chromatography (1:9 methanol/dichloromethane): MS (ES+) 212 (M+H); HPLC 1.121 minutes.
Workup
- temperaturethe mixture was refluxed for several hours
- customThe solvent was then evaporated
- customthe title product was purified by silica gel chromatography (1:9 methanol/dichloromethane)
- customHPLC 1.121 minutes
Sources & evidence
- ORD record
- ord-c3ba0c2379494d3b83df84c4964169fb
- Source dataset
- uspto-grants-2010_02
- Patent number
- US07666647B2
Reaction notes
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