5-Methoxypyridine-3-boronic Acid → 3-Methoxy-5-{4-[5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazol-2-yl]-phenyl}-pyridine

HRID 1445807

Reaction equation

HRID 1445807 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7](B(O)O)[CH:8]=1.Br[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:20][C:21]([CH3:31])=[C:22]([CH2:24][CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)[N:23]=2)=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[O:20][C:21]([CH3:31])=[C:22]([CH2:24][CH2:25][N:26]4[CH2:27][CH2:28][CH2:29][CH2:30]4)[N:23]=3)=[CH:15][CH:14]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 27630875-Methoxypyridine-3-boronic AcidHCID 116815462-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole

Product 1

HCID 116247413-Methoxy-5-{4-[5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazol-2-yl]-phenyl}-pyridine

Procedure

The title compound is prepared in a manner substantially analogous to Example 35 starting from 3-Methoxypyridine-5-boronic acid and 2-(4-Bromo-phenyl)-5-methyl-4-(2-pyrrolidin-1-yl-ethyl)-oxazole. MS (m/e): 364.2 (M+1)

Sources & evidence

ORD record
ord-8fb9ae878c874daeb8ba07d12b363dcc
Source dataset
uspto-grants-2010_02
Patent number
US07666871B2

Linked notes

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