2-Methoxyethanol → Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

HRID 1446932

Reaction equation

HRID 1446932 reaction equation
Cl.Cl[CH2:3][CH2:4][N:5]([CH2:9][CH2:10]Cl)[CH2:6][CH2:7]Cl.[CH3:12][O:13][CH2:14][CH2:15][OH:16]>>[CH2:4]([N:5]([CH2:9][CH2:10][O:16][CH2:15][CH2:14][O:13][CH3:12])[CH2:6][CH2:7][O:16][CH2:15][CH2:14][O:13][CH3:12])[CH2:3][O:16][CH2:15][CH2:14][O:13][CH3:12]

Participants

3

Reactant 2

HCID 80192-MethoxyethanolHCID 61220Tris(2-chloroethyl)amine hydrochloride

Product 1

HCID 112414Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

Procedure

51.6 g (namely, 0.215 mol) of tris-(2-chloroethyl)-amine hydrochloride were added to the above mixture. The mixture was subsequently heated at the reflux temperature of the 2-methoxyethanol (125° C.) for 12 hours and the solvent was then distilled under reduced pressure. The excess sodium 2-ethoxyethanolate was neutralized by adding 11.6 cm3 of aqueous HCl (10 N). The sodium chloride was filtered off and the solution was distilled.

Workup

  1. distillationthe solvent was then distilled under reduced pressure
  2. additionby adding 11.6 cm3 of aqueous HCl (10 N)
  3. filtrationThe sodium chloride was filtered off
  4. distillationthe solution was distilled

Sources & evidence

ORD record
ord-d7dc498ca4824ed08e49abeea1dc1b67
Source dataset
uspto-grants-1982_02
Patent number
US04314086

Linked notes

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