Potassium Hydroxide → 1-(1,3,4-Thiadiazol-2-yl)piperazine

Reaction equation

[OH-].[K+].[CH:3]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)=O.Br[C:12]1[S:13]C=[N:15][N:16]=1>>[S:13]1[CH:12]=[N:16][N:15]=[C:3]1[N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1

Participants

Reactant 3

HCID 14797Potassium Hydroxide

HCID 821911-Piperazinecarboxaldehyde

HCID 27951982-Bromo-1,3,4-thiadiazole

Product 1

HCID 202340691-(1,3,4-Thiadiazol-2-yl)piperazine

Procedure

The starting 1-(1,3,4-thiadiazol-2-yl)-piperazine was prepared by hydrolyzing with alcoholic potassium hydroxide the crude formyl derivative, itself prepared by condensing 1-formyl piperazine with 2-bromo-1,3,4-thiadiazole melting at 74° C. (Goerdeler and al., Ber 89 1534 (1956)).

Sources & evidence

ORD record: ord-9e58822d7c0d4b0191de488e537d79db
Source dataset: uspto-grants-1979_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04177272

Reaction notes

Loading…