3-Dimethylamino-4'-ethylacrylophenone → Ethyl 7-(p-ethylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

HRID 1447894

Reaction equation

HRID 1447894 reaction equation
C[N:2]([CH3:15])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH3:14])=[CH:9][CH:8]=1)=O.N[C:17]1[C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=C[NH:19][N:18]=1>C(O)(=O)C>[CH2:13]([C:10]1[CH:9]=[CH:8][C:7]([C:5]2[N:19]3[N:18]=[CH:17][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[C:15]3[N:2]=[CH:3][CH:4]=2)=[CH:12][CH:11]=1)[CH3:14]

Participants

4

Reactant 2

HCID 538338993-Dimethylamino-4'-ethylacrylophenoneHCID 178469928HCID 178469928, compound

Product 1

HCID 11483299Ethyl 7-(p-ethylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 4.07 g. of 3-dimethylamino-4'-ethylacrylophenone and 3.10 g. of ethyl 3-aminopyrazole-4-carboxylate in 25 ml. of glacial acetic acid is refluxed for 20 hours. The compound is recovered from the reaction in the previously described fashion to yield crystals, m.p. 101°-103° C.

Workup

  1. additionA mixture of 4.07 g
  2. customThe compound is recovered from the reaction in the previously described fashion
  3. customto yield crystals, m.p. 101°-103° C.

Sources & evidence

ORD record
ord-aca8d712d3184de7a05dab8455ee7c43
Source dataset
uspto-grants-1979_12
Patent number
US04178449

Linked notes

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