Propylene Glycol → Pilocarpine

HRID 1448028

Reaction equation

HRID 1448028 reaction equation
[CH3:1][CH2:2][C@@H:3]1[C:7](=[O:8])[O:6][CH2:5][C@@H:4]1[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1.[N+]([O-])(O)=O.C(O)C(O)C>>[CH3:1][CH2:2][C@@H:3]1[C:7](=[O:8])[O:6][CH2:5][C@@H:4]1[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1

Participants

3

Reactant 2

HCID 1030Propylene GlycolHCID 657349Pilocarpine Nitrate

Product 1

HCID 5910Pilocarpine

Procedure

A mixture of 16.25 parts by weight of 60 mesh pilocarpine nitrate and 83.38 parts by weight of hydroxypropyl cellulose are thoroughly mixed and to this mixture is added 8.37 parts of propylene glycol in a high shear mixer. A small amount of resulting mixture is then compressed using the procedures described in Example 2 to form a thin solid sheet of the mixture which is cut into rectangular shaped inserts about 10 mm. by 4 mm. having a thickness of about 0.8 mm. The ophthalmic inserts containing 3.4 mg. of pilocarpine so obtained were tested in the rabbit eye for moitic response with the following results:

Workup

  1. additionare thoroughly mixed and to this mixture
  2. customA small amount of resulting mixture
  3. customto form a thin solid sheet of the mixture which
  4. additionThe ophthalmic inserts containing 3.4 mg

Sources & evidence

ORD record
ord-ab038c764f2149ed99afbbf75b665af5
Source dataset
uspto-grants-1979_12
Patent number
US04179497

Linked notes

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