Ethyl bromoacetate → HCID 20375651, compound
Reaction equation
[F:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[O:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1.[Br:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>C(#N)C>[Br-:15].[CH2:20]([O:19][C:17](=[O:18])[CH2:16][N+:7]1[CH:8]=[CH:9][CH:10]=[C:5]([O:4][C:3]2[CH:11]=[CH:12][CH:13]=[CH:14][C:2]=2[F:1])[CH:6]=1)[CH3:21]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 1 g of 3-(2-fluorophenoxy) pyridine in 40 ml of acetonitrile is added 0.9 g of ethyl bromoacetate and the solution is refluxed 16 hours. The solvent is removed in vacuo to yield 1-(2-ethoxy-2-oxoethyl)-3-(2-fluorophenoxy) pyridinium bromide; mp 133°-135° C.
Workup
- temperaturethe solution is refluxed 16 hours
- customThe solvent is removed in vacuo
Sources & evidence
- ORD record
- ord-72c3c2dd40f14866b1bfb32b4220dc7b
- Source dataset
- uspto-grants-1980_02
- Patent number
- US04187311
Reaction notes
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