Sodium Hydroxide → HCID 13023173, compound

In a mixture of 50 ml of ethanol and 30 ml of benzene, 7.0 g (0.017 mole) of ethyl N-benzyl-o-(2,6-dichloroanilino)phenylacetate was dissolved and 31 ml of 2 N-NaOH aq. sol. was added and the mixture was stirred at about 80° C. for 9 hours. The reaction mixture was concentrated under reduced pressure and 70 ml of ether was added to the residue and the reaction product was extracted with 2 N-NaOH aq. sol. The pH of the water phase was adjusted with a dilute hydrochloric acid to 2.0 and the precipitate was extracted with ether and the ether phase was dried over anhydrous sodium sulfate and concentrated under a reduced pressure. The reaction product was recrystallized and 5.1 g of N-benzyl-o-(2,6-dichloroanilino)phenyl acetic acid was obtained as colorless crystals. Yield: 78%

1. dissolutionwas dissolved
2. concentrationThe reaction mixture was concentrated under reduced pressure and 70 ml of ether
3. additionwas added to the residue
4. extractionthe reaction product was extracted with 2 N-NaOH aq. sol. The pH of the water phase
5. extractionthe precipitate was extracted with ether
6. dry with materialthe ether phase was dried over anhydrous sodium sulfate
7. concentrationconcentrated under a reduced pressure
8. customThe reaction product was recrystallized

ORD record

ord-7c4b12e51d484d2ab8cd4ff522907608

Source dataset

uspto-grants-1980_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04189595