Cinchomeronic acid → 1H,3H-furo(3,4-c)pyridine-1,3-dione

HRID 1451471

Reaction equation

HRID 1451471 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[C:3]([C:10]([OH:12])=[O:11])[CH:2]=1>C(OC(=O)C)(=O)C>[N:1]1[CH:6]=[CH:5][C:4]2[C:7]([O:12][C:10](=[O:11])[C:3]=2[CH:2]=1)=[O:9]

Participants

3

Reactant 1

HCID 10273Cinchomeronic acid

Product 1

HCID 2783981H,3H-furo(3,4-c)pyridine-1,3-dioneYield 75.5%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A mixture of pyridine 3,4-dicarboxylic acid (15.0 g) and acetic anhydride (30 mL) is refluxed for two hours. The excess acetic anhydride is removed by distillation and the anhydride is collected and purified by sublimation (123° C. at 3 mm Hg) to yield pyridine 3,4-dicarboxylic acid anhydride as a white solid (10.1 g).

Workup

  1. temperatureis refluxed for two hours
  2. customThe excess acetic anhydride is removed by distillation
  3. customthe anhydride is collected
  4. custompurified by sublimation (123° C. at 3 mm Hg)

Sources & evidence

ORD record
ord-26848a4e1a04400080d48a23d17b4fcf
Source dataset
uspto-grants-1997_02
Patent number
US05604246

Linked notes

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