Potassium Hydroxide → HCID 22148934, compound
Reaction equation
[Br:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([CH2:18][C:19]([CH3:25])([CH3:24])[C:20]([O:22]C)=[O:21])=[C:8]2[CH3:26])=[CH:4][CH:3]=1.[OH-].[K+]>CCO>[Br:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([CH2:18][C:19]([CH3:25])([CH3:24])[C:20]([OH:22])=[O:21])=[C:8]2[CH3:26])=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a room temperature solution of the methyl ester from Step 2 (24 mg, 0.052 mmol) in 10 mL EtOH was added 1 mL of 4N KOH. The solution was heated to reflux for 22 h, then cooled and concentrated in vacuo. The residue was partitioned between 1M HCl and EtOAc. The organic layer was washed with brine, dried over Na2SO4 and evaporated to provide 23 mg of the title compound.