HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → N-(N-tert-butoxycarbonyl-3-phenyl-1H-indazol-5-yl)-3-fluorobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-Fluorobenzenesulfonyl Chloride | HCID 2734258 | — |
| Reactant | HCID 68874717 | HCID 68874717 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-(N-tert-butoxycarbonyl-3-phenyl-1H-indazol-5-yl)-3-fluorobenzenesulfonamide | HCID 22567057 | 74.4% |
Reaction Steps
N-(N-tert-Butoxycarbonyl-3-phenyl-1H-indazol-5-yl)-3-fluorobenzenesulfonamide can be obtained as described in Example 1 from 0.4 g of 5-amino-N-tert-butoxycarbonyl-3-phenyl-1H-indazole, 15 ml of tetrahydrofuran, 0.36 ml of triethylamine and 0.27 g of 3-fluorobenzenesulfonyl chloride. 0.45 g of N-(N-tert-butoxycarbonyl-3-phenyl-1H-indazol-5-yl)-3-fluorobenzenesulfonamide is thus obtained in the form of an ochre solid melting at 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07473701B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-cfbd3d455f624bd29b7f82cc8de0f2b1 |
| Source note | uspto-grants-2009_01 |