Reaction equation
Cl[C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]#[C:11][CH3:12])[N:5]=[CH:4][N:3]=1.[CH2:13]([CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][NH:16]1)[CH3:14]>>[CH2:9]([O:8][C:6]1[CH:7]=[C:2]([N:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH:15]2[CH2:13][CH3:14])[N:3]=[CH:4][N:5]=1)[C:10]#[C:11][CH3:12]Participants
3
Procedure
0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.56 g of 2-ethylpiperidine were mixed and left for 18 hours at 80° C. The reaction mixture was cooled to near room temperature and subjected to silica gel column chromatography to obtain 0.14 g of 4-(2-butynyloxy)-6-(2-ethylpiperidino)pyrimidine (hereinafter, referred to as Compound (22)).
Sources & evidence
- ORD record
- ord-04ef764e85d64f98abad7fe047736f5c
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07732448B2
Linked notes
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