5,6-Dichloro-1H-benzimidazole → HCID 178478377, compound

HRID 1453558

Reaction equation

HRID 1453558 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[Cl:12][C:13]1[C:21]([Cl:22])=[CH:20][C:16]2[N:17]=[CH:18][NH:19][C:15]=2[CH:14]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:17]2[C:16]3[CH:20]=[C:21]([Cl:22])[C:13]([Cl:12])=[CH:14][C:15]=3[N:19]=[CH:18]2)[N:3]=1

Participants

4

Reactant 2

HCID 3317755,6-Dichloro-1H-benzimidazoleHCID 53244122,6-Dichloropurine

Product 1

HCID 178478377HCID 178478377, compoundYield 53.8%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

567 mg of 2,6-dichloropurine, 6 ml of butanol and 617 mg of 5,6-dichlorobenzimidazole are mixed and brought to a temperature of 100° C. for approximately 24 hours. The mixture is allowed to return to ambient temperature. Partial drying, washing with isopropanol and drying under vacuum at 50° C. are carried out, and 548 mg of expected product are obtained, in the form of gray/black-colored crystals.

Workup

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with isopropanol
  4. customdrying under vacuum at 50° C.

Sources & evidence

ORD record
ord-76e0f40d11ff49809c50455260d74855
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Linked notes

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