Nicotinic acid, hydrazide → 3-(4-Methyl-5-(methylsulfonyl)-4H-1,2,4-triazol-3-yl)pyridine

Reaction equation

[CH3:1][N:2]1[C:6]([S:7]([CH3:10])(=[O:9])=[O:8])=[N:5][N:4]=[C:3]1[C:11]1[CH:16]=[CH:15]N=C[CH:12]=1.C(NN)(=O)C1C=CC=[N:20][CH:19]=1>>[CH3:1][N:2]1[C:6]([S:7]([CH3:10])(=[O:8])=[O:9])=[N:5][N:4]=[C:3]1[C:11]1[CH:12]=[N:20][CH:19]=[CH:15][CH:16]=1

Participants

Reactant 2

HCID 11112Nicotinic acid, hydrazide

HCID 221514774-(4-Methyl-5-(methylsulfonyl)-4H-1,2,4-triazol-3-yl)pyridine

Product 1

HCID 469283343-(4-Methyl-5-(methylsulfonyl)-4H-1,2,4-triazol-3-yl)pyridine

Procedure

The title compound was prepared analogously to 4-[4-methyl-5-(methylsulfonyl)-4H-1,2,4-triazol-3-yl]pyridine as described herein, via the corresponding sequence consisting of the corresponding steps, by starting from nicotinohydrazide instead of isonicotinohydrazide. 1H NMR: 3.59 (s, 3H), 3.99 (s, 3H), 7.52 (m, 1H), 8.02 (dt, 1H), 8.83 (dd, 1H), 8.91 (m, 1H).

Sources & evidence

ORD record: ord-34d846db096d4ff39a7df60442d4a5dc
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07476684B2

Reaction notes

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