Chloroacetone → HCID 68954281, compound

HRID 1453831Notes

Reaction equation

HRID 1453831 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([C:18]([O:20][CH3:21])=[O:19])=[N:11][NH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:23][C:24](=[O:26])[CH3:25]>>[CH2:1]([O:8][C:9]1[C:13]([C:14]([O:16][CH3:17])=[O:15])=[N:12][N:11]([CH2:23][C:24](=[O:26])[CH3:25])[C:10]=1[C:18]([O:20][CH3:21])=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 57528491dimethyl 4-benzyloxy-1H-pyrazole-3,5-dicarboxylate

Product 1

HCID 68954281HCID 68954281, compound

Procedure

The title compound was prepared from dimethyl 4-benzyloxy-1H-pyrazole-3,5-dicarboxylate using a procedure similar to that described in Example 2, Step 2, except that chloroacetone was used in place of bromo(phenyl)acetonitrile, and the silica gel chromatography gradient elution was 0-60% EtOAc/hexanes. 1H NMR (400 MHz, d6-DMSO) δ 7.46-7.34 (m, 5h), 5.44 (s, 2H), 5.06 (s, 2H), 3.83 (s, 3H), 3.78 (s, 3H), 2.20 (s, 3H); ES MS (M+1)=347.

Workup

  1. washthe silica gel chromatography gradient elution

Sources & evidence

ORD record
ord-abb64157dd76438fa6274af41ecf3731
Source dataset
uspto-grants-2009_01
Patent number
US07476666B2

Reaction notes

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