Ketamine → Esmolol

HRID 1454323

Reaction equation

HRID 1454323 reaction equation
[CH:1]1C=CC(SC[C@H]2O[C@@H](N3C4=NC=NC(N[C@H]5[C@H](O)CCC5)=C4N=C3)[C@H](O)[C@@H]2O)=C(F)C=1.CNC1(C2C=CC=CC=2Cl)C(=O)CCCC1.CC1C=CC=C(C)C=1NC1SCCCN=1.CC(C1C=CC2SC3C=CC=CC=3N(CCCN(C)C)C=2C=1)=O.[CH:87](/[C:92](O)=O)=[CH:88]/[C:89]([OH:91])=[O:90].[CH3:95][CH:96]([NH:98][CH2:99][CH:100]([OH:113])[CH2:101][O:102][C:103]1[CH:104]=[CH:105]C(CCOC)=[CH:107][CH:108]=1)[CH3:97].CC(NCC(O)COC1C=CC=C2C=CC=CC=12)C>CS(C)=O>[CH3:97][CH:96]([NH:98][CH2:99][CH:100]([OH:113])[CH2:101][O:102][C:103]1[CH:104]=[CH:105][C:92]([CH2:87][CH2:88][C:89]([O:91][CH3:1])=[O:90])=[CH:107][CH:108]=1)[CH3:95]

Participants

8

Reactant 6

HCID 3821KetamineHCID 4171MetoprololHCID 4946PropranololHCID 5707XylazineHCID 6420038Acepromazine MaleateHCID 11561692Gs-9667

Product 1

HCID 59768Esmolol

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Rats (Sprague Dawley) weighing 300-400 gms were purchased from Simonsen laboratories. CVT-3619 was dissolved in DMSO and further diluted in saline. CVT-510 was dissolved in saline. Ketamine was purchased from Fort Dodge Animal Health, Xylazine from Bayer and Acepromazine Maleate from Fermenta Animal Health Co. Metoprolol and propranolol were purchased from SIGMA. Esmolol was obtained from a local pharmacy.

Workup

  1. additionfurther diluted in saline
  2. dissolutionCVT-510 was dissolved in saline

Sources & evidence

ORD record
ord-4b75149209604688b19e1400bc412ecb
Source dataset
uspto-grants-2009_01
Patent number
US07479485B2

Linked notes

Loading…