Sodium Hydroxide → 5-(Methoxymethyl)-6-methylpyridin-2-amine

Reaction equation

[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([NH:11]C(=O)C(C)(C)C)=[N:8][C:9]=1[CH3:10].[OH-].[Na+]>>[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([NH2:11])=[N:8][C:9]=1[CH3:10]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 68841136N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide

Product 1

HCID 688455515-(Methoxymethyl)-6-methylpyridin-2-amine

Procedure

This material was prepared in analogy to example 86 step B) from N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide (0.4 g) and 3M aqueous NaOH (2.68 mL) as a crystalline orange solid (0.174 g). MS (EI): 152.2 (M+).

Sources & evidence

ORD record: ord-06d3617b524e40e997260002a0a89a23
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

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