Sodium Hydroxide → 6-(3-Chloro-benzyloxymethyl)-pyridin-2-ylamine

HRID 1454902Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[CH2:5][O:6][CH2:7][C:8]1[N:13]=[C:12]([NH:14]C(=O)C(C)(C)C)[CH:11]=[CH:10][CH:9]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[CH2:5][O:6][CH2:7][C:8]1[N:13]=[C:12]([NH2:14])[CH:11]=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 68842609HCID 68842609, compound

Product 1

HCID 688420116-(3-Chloro-benzyloxymethyl)-pyridin-2-ylamine

Procedure

This material was prepared in analogy to example 86 step B] from N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (0.75 g) and 3M aqueous NaOH (4.51 mL) as a brown liquid (0.56 g). MS (ESI): 249.1 (MH+).

Sources & evidence

ORD record: ord-49a404700ff84a23afe628e3915723bd
Source dataset: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07482341B2

Reaction notes

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