Nitric Acid → 5-bromo-6-nitro-2,3-dihydro-1H-inden-1-one

HRID 1455705

Reaction equation

HRID 1455705 reaction equation
[N+:1]([O-:4])(O)=[O:2].[Br:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[CH2:10][CH2:9]2>>[Br:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][C:14]=1[N+:1]([O-:4])=[O:2])[C:11](=[O:15])[CH2:10][CH2:9]2

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 5206955-Bromo-1-indanone

Product 1

HCID 534851495-bromo-6-nitro-2,3-dihydro-1H-inden-1-one

Procedure

Fuming nitric acid (166 ml) is cooled to −15° C., and 5-bromoindan-1-one (25 g, 0.118 mol) is then added portionwise. After stirring for 4 hours 30 minutes at between −10° C. and −15° C., the reaction mass is poured into ice-cold water (1600 ml).

Sources & evidence

ORD record
ord-1dc8686ba03a42cc8bf847e84f4e13de
Source dataset
uspto-grants-2009_01
Patent number
US07482484B2

Linked notes

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