Trimethylsilyl iodide → HCID 18797359, compound
Reaction equation
C1(C[O:5][C:6]2[CH:14]=[CH:13][CH:12]=[C:11]3[C:7]=2[C:8]([C:15]2[CH2:16][CH2:17][N:18]([CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:19][CH:20]=2)=[CH:9][NH:10]3)CC1.C[Si](I)(C)C>>[OH:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[C:8]([C:15]1[CH2:16][CH2:17][N:18]([CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:19][CH:20]=1)=[CH:9][NH:10]2Participants
3
Procedure
Following the procedure described in detail in Example 58, 1.2 gm (3.35 mMol) 4-cyclopropylmethoxy-3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole were reacted with trimethylsilyl iodide to provide 0.359 gm (35%) of the title compound as a tan solid.
Sources & evidence
- ORD record
- ord-09e449026d394e1c95bd48d75ed921eb
- Source dataset
- uspto-grants-1998_12
- Patent number
- US05846982