4-Chloro-6-ethyl-5-iodopyrimidine → HCID 178437701, compound

HRID 1458653

Reaction equation

HRID 1458653 reaction equation
Cl[C:2]1[C:7]([I:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1.[CH3:11][Si:12]([CH3:21])([CH3:20])[C@@H:13]1[CH2:18][CH2:17][C@H:16]([NH2:19])[CH2:15][CH2:14]1>>[CH2:9]([C:6]1([NH:19][C@H:16]2[CH2:15][CH2:14][C@@H:13]([Si:12]([CH3:21])([CH3:20])[CH3:11])[CH2:18][CH2:17]2)[NH:5][CH:4]=[N:3][CH:2]=[C:7]1[I:8])[CH3:10]

Participants

3

Reactant 2

HCID 109784874-Chloro-6-ethyl-5-iodopyrimidineHCID 178504289HCID 178504289, compound

Product 1

HCID 178437701HCID 178437701, compound

Procedure

Prepared as in Example 1 from 4-chloro-5-iodo-6-ethylpyrimidine and cis-4-trimethylsilylcyclohexylamine (yellow oil). The following compounds were further prepared analogously:

Workup

  1. customThe following compounds were further prepared analogously

Sources & evidence

ORD record
ord-da6d1888eb854afaa6e303296ae5f50e
Source dataset
uspto-grants-1998_12
Patent number
US05852023

Linked notes

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