HCID 22097108, compound → HCID 22097099, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:13]([O-])=O)=[C:6]([NH:8][CH2:9][C:10]([OH:12])=[O:11])[CH:7]=1>C(O)C.[Ni]>[NH2:13][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][C:6]=1[NH:8][CH2:9][C:10]([OH:12])=[O:11]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
19.5 g (84.6 mmol) of N-(5-chloro-2-nitrophenyl)glycine were dissolved in 250 ml of ethanol and, after addition of 5 g of Raney nickel, hydrogenated under 1 bar at 45°-50° C. The mixture was then filtered, and the filtrate was evaporated under reduced pressure to yield 15.6 g (93%) of the product.
Workup
- customat 45°-50° C
- filtrationThe mixture was then filtered
- customthe filtrate was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-bc4a9ad543d7438a99cf7a56535473cf
- Source dataset
- uspto-grants-1998_12
- Patent number
- US05852017
Reaction notes
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