Acetic Anhydride → 2-Acetamido-8-methoxytetralin

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2.[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][CH:10]([NH:13][C:14](=[O:16])[CH3:15])[CH2:9][CH2:8]2

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 101979338-Methoxy-2-aminotetralin

Product 1

HCID 30189202-Acetamido-8-methoxytetralinYield 69%

Procedure

Using a procedure similar to that described in Example 1, 0.30 g of 8-methoxy-2-amino-tetralin yielded 0.23 g (69%) of 8-methoxy-2-acetamido-tetralin following treatment with acetic anhydride.

Sources & evidence

ORD record: ord-afa1261adce34db0ab8a228dbdf30b1c
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05071875

Reaction notes

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