3,4-Dichlorophenol → Rac-4-[2-(3,4-dichloro-phenoxy)-propionylamino]-thiophene-3-carboxylic acid

Reaction equation

C[O:2][C:3]([C:5]1[C:9]([NH:10][C:11](=[O:15])[CH:12](Cl)[CH3:13])=[CH:8][S:7][CH:6]=1)=[O:4].[Cl:16][C:17]1[CH:18]=[C:19]([OH:24])[CH:20]=[CH:21][C:22]=1[Cl:23]>>[Cl:16][C:17]1[CH:18]=[C:19]([CH:20]=[CH:21][C:22]=1[Cl:23])[O:24][CH:12]([CH3:13])[C:11]([NH:10][C:9]1[C:5]([C:3]([OH:2])=[O:4])=[CH:6][S:7][CH:8]=1)=[O:15]

Participants

Reactant 2

HCID 72583,4-Dichlorophenol

HCID 68688356Rac-4-(2-chloro-propionylamino)-thiophene-3-carboxylic acid methyl ester

Product 1

HCID 16068683Rac-4-[2-(3,4-dichloro-phenoxy)-propionylamino]-thiophene-3-carboxylic acid

Procedure

In analogy to Example 2, the title compound was prepared using rac-4-(2-chloro-propionylamino)-thiophene-3-carboxylic acid methyl ester and 3,4-dichlorophenol. MS (m/e): 360.0 (M−H).

Sources & evidence

ORD record: ord-dfa3c45841c044c79e13a902739fee12
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732452B2

Reaction notes

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